Guy, M.W., Richards, J.E., Tonnsen, B., & Roberts, J.E. (2017). Neural correlates of face processing in etiologically-distinct 12-month-old infants at high-risk of autism spectrum disorder. Developmental Cognitive Neuroscience.
Neural correlates of face processing were examined in 12-month-olds at high-risk for autism spectrum disorder (ASD), including 21 siblings of children with ASD (ASIBs) and 15 infants with fragile X syndrome (FXS), as well as 21 typically developing (TD) controls. Event-related potentials were recorded to familiar and novel face and toy stimuli. All infants demonstrated greater N290 amplitude to faces than toys. At the Nc component, TD infants showed greater amplitude to novel stimuli than to their motherís face and own toy, whereas infants with FXS showed the opposite pattern of responses and ASIBs did not differentiate based on familiarity. These results reflect developing face specialization across high-risk and TD infants and reveal neural patterns that distinguish between groups at high-risk for ASD.