Richards, J.E. (2018). Development of Diffuse Optical Tomography sensitivity in infants: Brain localization of NIRS activity. Sackler Developental Psychobiology Meeting, Hawaii, January 2018(pdf )
‘Near-Infrared-Optical-Spectroscopy’ (NIRS) is a tool for neuroimaging in infant participants. NIRS measurement works by source/detector optodes placed on the scalp that measure reflected light from oxygenated / deoxygenated hemoglobin. Diffuse optical tomography (DOT) is used to describe the scattering of light through the interior of the head. The sensitivity profile derived from DOT may be used to identify the underlying cortical anatomy that is reflected to the detector optodes and the relative contributions of anatomical regions. The current study uses simulated photon migration programs to map the DOT sensitivity of infants in the first year. The results map the sensitivity of the infant head to light propagation. The DOT sensitivity profiles for individual infants is used to complement spatial projection methods and adds to a comprehensive database of scalp-location-to-cortical-anatomy for infants. These results were also compared to results for older age participants, and the sensitivity profiles for an age may be used in quantitative methods that use inverse modeling to show NIRS activity in the brain.